BIO 346 Human Biology (K. Kalthoff)

References to Topic 10: Cloning and Stem Cells

Easy Readings

Golde D.W. (1991) The stem cell. Scientific American 265 (December): 86–93.
Hochedlinger K. (2010) Your inner healers. Scientific American May 2010: 47-53
Lanza R. and Rosenthal N. (2004) The stem cell challenge.   Scientific American June 2004: 93-99
McKay R. (2000) Stem cells - hype and hope. Nature 406: 361-364.
Mooney D.J. and Mikos A.G. (1999) Growing new organs. Scient. Amer. 280 (April): 60-65.

Intermediate Readings

DiBerardino M.A., Hoffner N.J. and Etkin L.D. (1984) Activation of dormant genes in specialized cells. Science 224: 946–952.
Dimmeler S., Zeiher A.M. and Schneider M.D. (2005) Unchain my heart: the scientific foundations of cardiac repair.
Hench LL and Polak JM. (2002) Third-generation biomedical materials. Science 295: 1014-1017.
Hochedlinger K. and Jaenisch R. (2006) Nuclear reprogramming and pluripotency. Nature 441: 1059-1067
Moore K.A. and Lemischka I.R. (2006) Stem cells and their niches. Science 311: 1880-1885
Thomson J.A. and Marshall V.S. (1998) Primate embryonic stem cells. Curr. Top. Devel. Biol. 38: 133- 165.
Watt F.M. and Hogan B.L.M. (2000) Out of Eden: Stem cells and their niches. Science 287: 1427-1430

Advanced Readings

Ashworth D., Bishop M., Campbell K., Colman A., Kind A., Schnieke A., Blott S., Griffin H., Haley C., McWhir J., and Wilmut I. (1998) DNA microsatellite analysis of Dolly. Nature 394: 329.
Bjornson C.R., Rietze R.L., Reynolds B.A., Magli M.C. and Vescovi A.L. (1999) Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283: 534-537.
Byrne J.A. et a. (2007) Producing primate embryonic stem cells by somatic nuclear transfer. Nature 450: 497-502
Eiraku M. (2011) Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472: 51-
Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A. and Gage F.H. (1998) Neurogenesis in the adult human hippocampus. Nat. Med. 4:1313-1317.
Gaspar-Maia A. et al. (2009) Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature 460: 863-868
Geijsen N., Horoschak M., Kim K., Gribnau J., Eggan K. and Daley G.O. (2004) Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature 427: 148-154
Gnecchi et al., 2005) Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nature Medicine 11: 347-348
Guan K, Nayernia K, Maier LS, Wagner S, Dressel R, Lee JH, Nolte J, Wolf F, Li M, Engel W, Hasenfuss G. (2006) Pluripotency of spermatogonial stem cells from adult mouse testis. Nature 440: 1199-203
Harris R.G., Herzog, e.L., Bruscia E.M., Grove J.E., Van Arnam J.S. and Krause D.S. (2004) Lack of a fusion requirement for development of boine marrow-derived epithelia. Science 305: 90-93
Hayashi K. et al. (2011) Reconstitution of the mouse germ line specification pathway in culture by pluripotent stem cells. Cell 146: 519-532
Hayashi K. et al. (2012) Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice. Science 338: 971-975
Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK. (2002) Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A. 99: 16105-16110.Huebner K. et al. (2003) Derivation of oocytes from mouse embryonic stem cells. Science 300: 1251-1256
Hwang WS, Ryu YJ, Park JH, Park ES, Lee EG, Koo JM, Jeon HY, Lee BC, Kang SK, Kim SJ, Ahn C, Hwang JH, Park KY, Cibelli JB, Moon SY (2004) Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. Science 303: 1669-1674.
Hwang W.S. et al. (2005) Patient-specific embryonic stem cells derived from human SCNT blastocysts. Science 308: 1777-1783
Johansson C.B., Momma S., Clarke D.L., Risling M., Lendahl U. and Frisen J. (1999) Identification of a neural stem cell in the adult mammalian central nervous system. Cell 96: 25-34.
Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez-Pernaute R, Bankiewicz K, McKay R. (2002) Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418: 50-56.
Klimanskaya I, Chung Y, Becker S, Lu SJ, and Lanza R (2006) Human embryonic stem cell lines derived from single blastomeres. Nature 444: 481-485
Kriks S. et al. (2011) Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 480: 547-551
Mavilio F. et al. (2006) Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nature Medicine 12: 1397-1402

McCreath K.J., Howcroft J., Campbell K.H.S., Colman A., Schnieke A.E. and Kind A.J. (2000) Production of gene-targeted sheep by nuclear transfer from cultured somatic cells. Nature 405: 1066-1069
Nayernia K. et al. (2006) In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice. Developmental Cell 11: 125-132
Rideout III W.M., Hochedlinger K., Kyba M., Daley G.Q. and Jaenisch R. (2002) Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 109: 17-27
Schnieke A.E., Kind A.J., Ritchie W.A., Mycock K., Scott A.R., Ritchie M., Wilmut I., Colman A., and Campbell K.H. (1997) Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278: 2130-2133.
Shiels P.G., Kind A.J., Campbell K.H., Waddington D., Wilmut I., Colman A., and Schnieke A.E. (1999) Analysis of telomere lengths in cloned sheep. Nature 399: 316-317.
Signer E.N., Dubrova Y.E., Jeffreys A.J., Wilde C., Finch L.M., Wells M., and Peaker M. (1998) DNA fingerprinting Dolly. Nature 394: 329-330.
Studer L., Tabar V., McKay R.D. (1998) Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat. Neurosci. 1: 290-295.
Tian XC, Xu J, Yang X. (2000) Normal telomere lengths found in cloned cattle. Nat Genet. 26: 272-273Toyooka Y., Tsunekawa N., Akasu R. and Noce T. (2003) Embryonic stem cells can form germ cells in vitro. Proc.Natl.Acad.Sci.USA 100: 11457-11462
Wilmut I., Schnieke A.E., McWhir J., Kind A.J., and Campbell K.H.S. (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385: 810-813.
Yandava B.D., Billinghurst L.L. and Snyder E.Y. (1999) "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc. Natl. Acad. Sci. U S A 96: 7029-7034
Yoo J.J. et al. (2011) Regenerative medicine strategies for treating neurogenic bladder. Int. Neurolog. J. 15: 109-119


The U.S. National Academies, Institute of Medicine, and National Research Council have released statements calling for a ban on reproductive cloning of humans and for aggressive pursuit of stem cell research including therapeutic cloning of immunologically compatible replacement cells.

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