BIO 346 Human Biology (K. Kalthoff)

References to Topic 12: Senescence


Easy Readings

Greider C.W. and Blackburn E.H. (1996) Telomeres, telomerase, and cancer. Scientific American Feb.1996: 92-97
Hayflick L. (1994) How and Why We Age. New York: Ballantine Books.
Medawar P.B. (1957) An unsolved problem of biology. In: The Uniqueness of the Individual. London: Methuen.

Intermediate Readings

Arking R. (1991) Biology of Aging. Prentice Hall.
Finch C.E. (1990) Longevity, Senescence, and the Genome. Chicago: The University of Chicago Press.
Hornsby P.J. (2007) Telomerase and the aging process. Experimental Gerontology 42: 575-581
Kirkwood T.B.L. (1996) Human senescence. BioEssays 18: 1009-1016
Lamberts S.W., van den Beld A.W., and van der Lely A.-Jan (1997) The endocrinology of aging. Science 278: 419-424
Lithgow G.J. (1996) Invertebrate gerontology: the age mutations of Caenorhabditis elegans. BioEssays 18: 809-815.
Martin G.M. (2002) The evolutionary substrate of aging. Arch.Neurobiol. 59: 1702-1705
Rose M. (1991) Evolutionary Biology of Aging. England: Oxford University Press.
Tower J. (1996) Aging mechanism in fruit flies. Bioessays 18: 799-807
Zakian V.A. (1997) Life and cancer without telomerase. Cell 91: 1-3

Advanced Readings

Austad S. (1993) Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana). J. Zool. 229: 695-708
Blackburn E.H. (1991) Structure and function of telomeres. Nature 350: 569-573.
Blasco M.A., Funk W., Villeponteau B., and Greider C.W. (1995) Functional characterization and developmental regulation of mouse telomerase RNA. Science 269: 1267-1270.
Busciglio J. and Yankner B.A. (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378: 776-779
Carney J.M., Starke-Reed P.E., Oliver C.N., Landum R.W., Cheng M.S., Wu J.F. and Floyd R.A. (1991) Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc. Natl. Acad. Sci. USA. 88: 3633-3636.
Emerit I. and Chance B. (Eds.) (1992) Free Radicals and Aging. Switzerland: Birkhaeuser.
Feng J., Funk W.D., Wang S.-S, Weinrich S.L., Avilion A.A., Chiu C.-P, Adams R.R., Chang E., Allsopp R.C., Yu J., Le S., West M.D., Harley C.B., Andrews W.H., Greider C.W., and Villeponteau B. (1995) The RNA component of human telomerase. Science 269: 1236-1241.
Fridovich I. (1978) The biology of oxygen radicals. Science 201: 875-880.
Gustafsson L. and Part T. (1990) Acceleration of senescence in the collared flycatcher Ficedula albicollis by reproductive costs. Nature 347: 279-281.
Irani K. et al. (1997) Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science 275: 1649-1652
Jaskelioff M. et al. (2011) Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469: 102-106
Johnson T.E. (1990) Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249: 908-911.
Kenyon C., Chang J., Gensch E., Rudner A. and Tabtiang R. (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
Kim N.W., Piatyszek M.A., Prowse K.R., Harley C.B., West M.D., Ho P.L.C., Coviello G.M., Wright W.E., Weinrich S.L., and Shay J.W. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
Koruso H. et a. (2005) Suppression of aging in mice by the hormone Klotho. Science 309: 1829-1833
Lundblad V. and Wright W.E. (1996) Telomeres and telomerase: a simple picture becomes complex. Cell 87: 369-375
Mertz D.B. (1975) Senescent decline in flour beetle strains selected for early adult fitness. Physiological Zoology 48: 1-23.
Orr W.C. and Sohal R.S. (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263: 1128-1130.
Partridge L. and Barton N.H. (1993) Optimality, mutation, and the evolution of ageing. Nature 362: 305-311.
Sgrò C.M. and Partridge L. (1999) A delayed wave of death from reproduction in Drosophila. Science 286: 2521-2524
Sokal R.R. (1970) Senescence and genetic load: evidence from Tribolium. Science 167: 1733-1734.
Speakman J.R. et al. (2004) Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell 3: 87-95. See also Van Voorhies W.A. (2004) Live fast - live long? A commentary on a recent paper by Speakman et al. Aging Cell 3: 1-4
Stadtman E.R. (1992) Protein oxidation and aging. Science 257: 1220 1224.
Stein G.H. and Dulic V. (1995) Origins of G1 arrest in senescent human fibroblasts. BioEssays 17: 537-543.
Thomas M., Yang L. and Hornsby P.J. (2000) Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.   Nature Biotechnology 18: 39-42   See also comment by Shay J.W. and Wright W.E. (2000) The use of telomerized cells for tissue engineering. Nature Biotechnology 18: 22-23
Walker D.W., McColl G., Jenkins N.L., Harris J. and Lithgow G.J. (2000) Evolution of Lifespan in C. elegans. Nature 405: 296-297


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