Patterning Effect of Notochord on Neural Tube (pp.308-311)
Determination of Neural Crest Cells (p. 326)
p. 305, Fig. 13.2, the label "Epidermal Placodes" should be "Ectodermal Placodes".
Altmann C.R. and Brivanlou A.H. (2001) Neural patterning in the vertebrate embryo. Int Rev Cytol. 203: 447-482
Baker C.V.H. and Bronner-Fraser M. (2001) Vertebrate Cranial Placodes. I. Embryonic Induction. Devel.Biol. 232: 1-61
Christiansen JH, Coles EG, Wilkinson DG. (2000) Molecular control of neural crest formation, migration and differentiation. Curr Opin Cell Biol. 12: 719-724.
McMahon A.P. (2000) Neural patterning: The role of Nkx genees in the ventral spinal cord. Genes & Devel. 14: 2261-2264
Moens C.B. and Prince V.E. (2002) Constructing the Hindbrain: Insights from the Zebrafish. Devel.Dynam. 224: 1-17
Sieber-Blum M. (2000) Factors controlling lineage specification in the neural crest. (2000) Int Rev Cytol. 197: 1-33
Thisse C. and Zon L.I. (2002) Organogenesis--heart and blood formation from the zebrafish point of view. Science 295: 457-462
Odenthal J., van Eden F.J.M., Haffter P., Ingham P.W. and Nüsslein-Volhard C. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Devel. Biol. 219: 350-363
The zebrafish floor plate is about three cells wide, consisting of a medial floor plate (MFP) row of cells expressing both sonic hedgehog+ and fkd4+, and two lateral floor plate (LFP) rows expressing fkd4+ but not shh+. Mutagenesis screen have revealed several mutants in which either MFP or LFP cells are absent. The mutant phenotypes, and the observation that injection of shh mRNA increases the number of LFP but not MFP cells, indicate that shh synthesized in notochord and/or MFP cells induces LFP cell formation.
Lee K.J., Dietrich P. and Jessell T.M. (2000) Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature 403: 734-740
In order to investigate the role of the dorsal roof plate in neuronal patterning, the researchers devised a genetic method for killing roof plate cells. They accomplished this by expressing an introduced gene for a diphteria toxin selectively in roof plate cells. They found that mouse embryos without a roof plate were also lacking all the interneuron subtypes normally generated in the dorsal third of the neural tube. By lineage analysis, they showed that the lacking interneurons are not descendants of roof plate cells, so they are not missing simply because their progenitors have been killed. Rather, the normal development of the dorsal interneurons must depend on one or more signals released from the roof plate.
Great SEMs and drawings of mouse and human embryonic development may be found on this web site, which is slated for additional illustrations of pre-implantation and fetal development as well as the genesis of birth defects.
The Multidimensional Human Embryo is funded by the National Institute of Child Health and Human Development (NICHD) and provides a three-dimensional image reference of the Human Embryo based on magnetic resonance imaging.
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