MOL190

Fall, 2002

University of Texas at Austin

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Group 1: Tuesday, October 1 -HIV

An effective AIDS Vaccine Based on Live Attenuated Vesicular Stomatitis Virus Recombinants Cell 106:539 (2001)

HIV-1 Infection Requires a Functional Integrase NLS Molecular Cell 7: 1025-1036 (2001)

Modulation of HIV-1 replication by RNA interference Nature:418:435- 438 (2002)

Long-term RNase P-mediated inhibition of HIV-1 replication and pathogenesis Gene Therapy 8: 1863-1871 (2001)

Group 5: Thursday, October 3 -SURVIVAL PROTEINS

BCL-2, BCL-X Sequester BH3 Domain-only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis Molecular Cell 8 (2001)

Heat-shock protein 70 antagonizes apoptosis-inducing factor Nature Cell Biology 3 (2001)

Identification of XAF1 as an antagonist of XIAP anti-caspase activity Nature Cell Biology 3 (2001)

IAP Suppression of Apoptosis Involves Distinct mechanisms Mol Cell Biol 22 (2002)

Group 2: Tuesday October 8- PROTEIN FOLDING AND DISEASE

"Identification of a Novel Human Islet Polypeptide Beta-sheet Domain and Factors Influencing Fibrillogenesis" Journal of Molecular Biology, Volume

308 pp 515-525 (May 2001)

CHIP is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity. Molecular Cell (2002)

Prion Peptide paper JBC 277 (2002)

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature, 385: 787-93

 

Group 6: Thursday, October 10 - NEW ASPECTS IN GENE REGULATION: RNAI AND MICRORNA

Short interfering RNA confers intracellular antiviral immunity in human cells Nature: 418:434 (2002)

Prediction of Plant MicroRNA Targets Cell 120: 513 (2002)

Induction and Suppression of RNA Silencing by an Animal Virus Science 296:1321 (2002)

Short interfering RNA confers intracellular antiviral immunity in human cells Nature 418: 430 (2002)

A MicroRNA in a Multiple-turnover RNAi Enzyme Complex Sciencexpress Aug, 2002

Group 3: Tuesday, October 15 - ORIGINS OF CANCER

Replication Failure, Genome Instability and Increased Cancer Susceptibility in Mice with a Point Mutation in the DNA Ligase I Gene Cancer Research

Securin is Required for Chromosomal Stability in Human Cells Cell 105 (2001)

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans Nature Genetics 28: (2001)

Intestinal adenomas can develop with a stable karyotype and stable microsatellites PNAS 99 (2002)

 Group 7: Thursday, October 17 - PROTEONOMICS IN DRUG DISCOVERY

Profiling protein function with small molecule microarrays PNAS (2002)

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness PNAS (2002)

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype Nature Biotechnology 20:805 (2002)

Functional Discovery via a Compendium of Expression Profiles Cell 102:109 (2000)

 

GROUP 4: Tuesday, October 22 - STEM CELL DIFFERENTIATION

"Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells" Nature Genetics Vol 24 April 2000 372-376

Isolation of multipotent adult stem cells from the dermis of mammalian skin..Nat Cell Biol. 2001 Sep;3(9):778-84

Differentiation of Embryonc Stem Cells is Induced by GATA factors" Genes and Development 16:784 (2002)

A conserved RNA-binding protein controls germline stem cels in Caenorhabditis elegans." Nature. 2002 Jun 6;417(6889):660-3

Group 8: Thursday, October 24 - ANTIGEN PROCESSING

Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane Nature 418:988 (2002)

The kinetic basis of peptide exchange catalysis by HLA-DM" PNAS 98: 12450 (2001)

Glycosylation Signals that Separate the Trimerization from the MHC Class II-binding Domain control intracellular degradation of invariant chain" JBC 276:13469-13475 (2001)